A depressants drug obviously arrests the brain function and alters its function. These depressants gradually decrease the activity of the brain. Moreover it increases the gamma amino butyric acid activity which is responsible of the inhibition of neurons. So when the activity of the GABA is increased, users will feel drowsy and calm, this may be helpful for the people who are suffering from sleeping disorders.

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Drug addiction greatly affects the central nervous system. Treating the drug addiction is reasonably difficult because it affects the frontal cortex of the brain by the negative mechanism which acts as the site for decision making and behavior. Cognition and behavior of a person is controlled by the frontal cortex of the brain. It is found that the frontal cortex is weaker due to drug addiction whereas the normal individual brain was healthy. Drugs take over the activity of brain and alter them and they do not substitute the occupation of the brain.

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