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Test Calibrator Cut off
Cocaine (COC) Benzoylecgonine 300 ng/mL
Amphetamine (AMP) D-Amphetamine 1,000 ng/mL
Methamphetamine (mAMP) D-Methamphetamine 1,000 ng/mL
Marijuana (THC) 11-nor-∆9-THC-9 COOH 50 ng/mL
Opiates (OPI 2000) Morphine 2,000 ng/mL
Phencyclidine (PCP) Phencyclidine 25 ng/mL
Benzodiazepines (BZO) Oxazepam 300 ng/mL
Tricyclic Antidepressants (TCA) Nortriptyline 1,000 ng/mL
Oxycodone.(OXY) 6-Acetylcodeine 25,000
Methadone (MTD) Methadone 300 ng/mL
Ecstasy (MDMA) DL-3,4-Methylenedioxymethamphetamine HCI (MDMA) 500ng/ml
Barbiturates (BAR) Secobarbital 300 ng/mL
Propoxyphene(PPX)    

About Cocaine (COC)

Cocaine is a potent central nervous system (CNS) stimulant and a local anesthetic. Initially, it brings about extreme energy and restlessness while gradually resulting in tremors, over-sensitivity and spasms. In large amounts, cocaine causes fever, unresponsiveness, difficulty in breathing and unconsciousness. Cocaine is often self-administered by nasal inhalation, intravenous injection and free-base smoking. It is excreted in the urine in a short time primarily as Benzoylecgonine.

About Amphetamine (AMP)

Amphetamine is a Schedule II controlled substance available by prescription (Dexedrine®) and is also available on the illicit market. Amphetamines are a class of potent sympathomimetic agents with therapeutic applications. They are chemically related to the human body’s natural catecholamines: epinephrine and norepinephrine. Acute higher doses lead to enhanced stimulation of the central nervous system and induce euphoria, alertness, reduced appetite, and a sense of increased energy and power.

About Methamphetamine (mAMP)

Methamphetamine is an addictive stimulant drug that strongly activates certain systems in the brain. Methamphetamine is closely related chemically to amphetamine, but the central nervous system effects of Methamphetamine are greater. Methamphetamine is made in illegal laboratories and has a high potential for abuse and dependence. The drug can be taken orally, injected, or inhaled. Acute higher doses lead to enhanced stimulation of the central nervous system and induce euphoria, alertness, reduced appetite, and a sense of increased energy and power. Cardiovascular responses to Methamphetamine include increased blood pressure and cardiac arrhythmias. More acute responses produce anxiety, paranoia, hallucinations, psychotic behavior, and eventually, depression and exhaustion. The effects of Methamphetamine generally last 2-4 hours and the drug has a half-life of 9-24 hours in the body. Methamphetamine is excreted in the urine as amphetamine and oxidized and deaminated derivatives. However, 10-20% of Methamphetamine is excreted unchanged. Thus, the presence of the parent compound in the urine indicates Methamphetamine use. Methamphetamine is generally detectable in the urine for 3-5 days, depending on urine pH level. The One Step Drug Screen Test Card yields a positive result when the Methamphetamine in urine exceeds 1,000 ng/mL.

About Marijuana(THC)

THC (∆9--tetrahydrocannabinol) is the primary active ingredient in cannabis (marijuana). When smoked or orally administered, THC produces euphoric effects. Users have impaired short term memory and slow learning. They may also experience transient episodes of confusion and anxiety. Long-term, relatively heavy use may be associated with behavioral disorders. The peak effect of marijuana administered by smoking occurs in 20-30 minutes and the duration is 90-120 minutes after one cigarette. Elevated levels of urinary metabolites are found within hours of exposure and remain detectable for 3-10 days after smoking.

About Methadone (MTD)

Methadone is a narcotic analgesic prescribed for the management of moderate to severe pain and for the treatment of opiate dependence (heroin, Vicodin, Percocet, Morphine). The pharmacology of Oral Methadone is very different from IV Methadone. Oral Methadone is partially stored in the liver for later use. IV Methadone acts more like heroin. In most states you must go to a pain clinic or a Methadone maintenance clinic to be prescribed Methadone.

About Opiate(2000) (OPI)

The One Step Drug Screen Test Card yields a positive result when the morphine in urine exceeds 2,000 ng/mL. This is the suggested screening cut-off for positive specimens set by the Substance Abuse and Mental Health Services Administration (SAMHSA, USA).

About Phencyclidine (PCP)

Phencyclidine, also known as PCP or Angel Dust, is a hallucinogen that was first marketed as a surgical anesthetic in the 1950’s. It was removed from the market because patients receiving it became delirious and experienced hallucinations. Phencyclidine is used in powder, capsule, and tablet form. The powder is either snorted or smoked after mixing it with marijuana or vegetable matter. Phencyclidine is most commonly administered by inhalation but can be used intravenously, intra-nasally, and orally. After low doses, the user thinks and acts swiftly and experiences mood swings from euphoria to depression. Self-injurious behavior is one of the
devastating effects of Phencyclidine.

About Barbiturate (BAR)

Barbiturates are central nervous system depressants. They are used therapeutically as sedatives, hypnotics, and anticonvulsants. Barbiturates are almost always taken orally as capsules or tablets. The effects resemble those of intoxication with alcohol. Chronic use of barbiturates leads to tolerance and physical dependence. Short acting Barbiturates taken at 400 mg/day for 2-3 months can produce a clinically significant degree of physical dependence. Withdrawal symptoms experienced during periods of drug abstinence can be severe enough to cause death. Only a small amount (less than 5%) of most Barbiturates are excreted unaltered in the urine.

About Benzodiazepines (BZO)

Benzodiazepines are medications that are frequently prescribed for the symptomatic treatment of anxiety and sleep disorders. They produce their effects via specific receptors involving a neurochemical called gamma aminobutyric acid (GABA). Because they are safer and more effective, Benzodiazepines have replaced barbiturates in the treatment of both anxiety and insomnia. Benzodiazepines are also used as sedatives before some surgical and medical procedures, and for the treatment of seizure disorders and alcohol withdrawal. Risk of physical dependence increases if Benzodiazepines are taken regularly (e.g., daily) for more than a few months, especially at higher than normal doses. Stopping abruptly can bring on such symptoms as trouble sleeping, gastrointestinal upset, feeling unwell, loss of appetite, sweating, trembling, weakness, anxiety and changes in perception. Only trace amounts (less than 1%) of most Benzodiazepines are excreted unaltered in the urine; most of the concentration in urine is conjugated drug. The detection period for the Benzodiazepines in the urine is 3-7 days. The One Step Drug Screen Test Card yields a positive result when the Benzodiazepines in urine exceed 300 ng/mL.

About Tricyclic (TCA)

TCA (Tricyclic Antidepressants) are commonly used for the treatment of depressive disorders. TCA overdoses can result in profound central nervous system depression, cardiotoxicity and anticholinergic effects. TCA overdose is the most common cause of death from prescription drugs. TCAs are taken orally or sometimes by injection. TCAs are metabolized in the liver. Both TCAs and their metabolites are excreted in urine mostly in the form of metabolites for up to ten days. The One Step Drug Screen Test Card yields a positive result when the concentration of Tricyclic Antidepressants in urine exceeds 1,000 ng/mL.

About Ecstasy (MDMA)

Methylenedioxymethamphetamine (ecstasy) is a designer drug first synthesized in 1914 by a German drug company for the treatment of obesity. Those who take the drug frequently report adverse effects, such as increased muscle tension and sweating. MDMA is not clearly a stimulant, although it has, in common with amphetamine drugs, a capacity to increase blood pressure and heart rate. MDMA does produce some perceptual changes in the form of increased sensitivity to light, difficulty in focusing, and blurred vision in some users. Its mechanism of action is thought to be via release of the neurotransmitter serotonin. MDMA may also release dopamine, although the general opinion is that this is a secondary effect of the drug (Nichols and Oberlender, 1990). The most pervasive effect of MDMA, occurring in virtually all people who took a reasonable dose of the drug, was to produce a clenching of the jaws. Methylenedioxymethamphetamine

About Oxycodone (OXY)

RapidOneTM OXY is a competitive immunoassay utilizing a highly specific reaction between antibodies and antigens for the detection of oxycodone in urine. The length of time following drug use for which a positive result may occur is dependent upon several factors including frequency and amount of drug, metabolic rate, excretion rate, drug half-life, and the drug user’s age, weight, activity, and diet.

About Propoxyphene (PPX)

Propoxyphene is a prescription drug for the relief of pain. Propoxyphene hydrochloride (Darvon, Dolene, and others) is available in 32mg and 65mg capsules; propoxyphene napsylate (Darvon-N) is available in 100mg tablets or as a suspension. It is structurally related to methadone. Overdose of the drug can affect the brain region and cause euphoria as many opioids do. The progressive symptomatology of propoxyphene includes analgesia, stupor, respiratory depression, and coma, etc. The half-life of propoxyphene is 8-24 hours. Following oral administration, propoxyphene reaches its peak in 1 to 2 hours. There is great variability between subjects in the rate of clearance. The percentage of excreted unchanged propoxyphene in urine is less than 1%. The major metabolite of propoxyphene is norpropoxyphene Therefore, the detection of norpropoxyphene is widely used for the testing of propoxyphene abuse. The half-life of norpropoxyphene is about 30 hours, and its accumulation with repeated doses may be responsible for some of the toxicity observed.

Analitical Specificity

A drug-free urine pool was spiked with drugs at concentrations listed. The results are summarized below.

Compound Concentration(ng/ml)

COCAINE

Benzoylecgonine
 

300
Cocaine HCl 780
Cocaethylene 12,500
Ecgonine HCl 32,000

AMPHETAMINE

D-Amphetamine 1,000
L-Amphetamine 50,000
(±)3,4-Methylenedioxyamphetamine 2,000
Phentermine 3,000

METHAMPHETAMINE

ρ-Hydroxymethamphetamine
 

30,000
L-Methamphetamine 8,000
(±)-3,4-Methylenedioxymethamphetamine 2,000

MARIJUANA (THC)

11-nor-∆9 -THC-9 COOH

50
Cannabinol 20,000
11-nor-∆8-THC-9 COOH 30
∆8 –THC 15,000
∆9 -THC 15,000

METHADONE

Methadone

300
Doxylamine 50,000

OPIATES (2000)

Morphine

2,000
Codeine 2,000
Ethylmorphine 5,000
Hydrocodone 12,500
Levophanol 75,000
6-Monoacetylmorphine 5,000
Morphine 3-β-D-glucuronide 2,000
Norcodeine 12,500
Normorphone 50,000
Oxycodone 25,000
Oxymorphone 25,000
Procaine 150,000

PCP

Phencyclidine

25

BARBITURATES

Secobarbital

300
Amobarbital 300
Alphenol 150
Aprobarbital 200
Butalbital 2,500
Butethal 100
Cyclopentobarbital 600
Pentobarbital 300
Phenobarbital 100

BENZODIAZEPINES

Oxazepam

300
Alprazolam 196
a-Hydroxyalprazolam 1,262
Bromazepam 1,562
Chlordiazepoxide 1,562
Chlordiazepoxide HCI 781
Clobazam 98
Clonazepam 781
Clorazepate dipotassium 195
Delorazepam 1,562
Desalkylflurazepam 390
Diazepam 195
Estazolam 2,500
Flunitrazepam 390
   

OXYCODONE

6-Acetylcodeine

25,000
6-acetylmorphine 75,000
Codeine 12,500
Hydromorphone 2,500
Hydrocodone 625
Morphine 6,250
Noroxycodone 50,000
Oxycodone 100
Oxymorphone 100
Thebaine 25,000

PROPOXYPHENE

 
d-Propoxyphene 300
d-Norpropoxyphene 300

ECSTASY

 

DL-3,4-Methylenedioxymethamphetamine HCI (MDMA)
 

500
3,4-Methylenedioxyamphetamine HCI (MDA) 3,000
3,4-Methylenedioxyethyl-amphetamine (MDE) 300

TRICYCLIC ANTIDEPRESSANTS

 

Notriptyline

1,000
Nordoxepine 1,000
Trimipramine 3,000
Amitriptyline 1,500
Promazine 1,500
Desipramine 200
Clomipramine 12,500
Doxepine 2,000
Maprotiline 2,000
Promethazine 2,500